Endocrine Abstracts

T2DM is expected to rise to 552 million by 2030. DM is associated with complications which result in reduced quality of life and premature mortality.T2DM has a long asymptomatic pre-clinical phase (~5–10 years) which frequently goes undetected. Benefits of early diagnosis on outcomes in screen-detected DM remain unclear. Some indirect evidence suggesting that early detection and intervention may be beneficial.Screening for DM ...

Introduction: Pro-opiomelanocortin (POMC) is a precursor polypeptide which is cleaved to make adrenocorticotrophic hormone (ACTH) in the anterior pituitary. It is activated in Cushing’s disease. Current therapies for Cushing’s disease are inadequate. RNA interference (RNAi) allows highly specific and effective suppression of gene expression by use of short interfering RNAs (siRNAs).Method: In the current study we employed custom designed siRNAs...

Background: Proopiomelanocortin gene (POMC) and its cleaved product adrenocorticotrophin hormone (ACTH) play an important role in regulation of the hypothalamo-pituitary-adrenal (HPA) axis. ACTH stimulates the adrenal glands to release glucocorticoids. Glucocorticoid has a suppressive effect on ACTH and POMC. This suppression remains long after withdrawal, and may lead to adrenocortical insufficiency. POMC expression is dependent on the activities of some of the positively act...